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Tildren

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  • Tildren

    I was wondering if anyone has used this drug (Tildren)? What were your experiences - did it help? It seems very pricey!

  • #2
    We used it on a horse some time last year and actually just (as in Thursday) gave it to another horse. Too early to tell on the second horse, but it DID help the first horse a great deal for awhile, along with some other things.
    Amanda

    Comment


    • #3
      Lots of threads on it.

      Do a search with both "Tildren" and "Tildrin".

      Especially from RAyers.
      Janet

      chief feeder and mucker for Music, Spy, Belle and Tiara. Someone else is now feeding and mucking for Chief and Brain (both foxhunting now).

      Comment


      • #4
        We have used it SEVERAL times, always with positive results...

        Comment


        • #5
          How does it work and what is the cost? I take it this is for navicular horses?
          www.oakhollowstable.blogspot.com

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          • #6
            I had it done for my ringbone horse via regional profusion ,rather than the whole horse ,as it is much cheaper,and was concentrated to his specific problem area. I felt that he improved significantly. It cost me around 200.00.
            I have heard they have been trying it for navicular.The drug is not approved in this country ,but is used by some vets over here. there have been no scientific studies of it's effectiveness,but the anecdotal evidence has been quite positive.not sure how much it has been used for navicular.
            I think it works to stop the process of laying down more bone,or inhibits the boney changes.it is used for arthritic type conditions.To do the iv route for the entire horse it is about 1000.00. Some of the big show jumpers use it.
            Last edited by horsekpr; Apr. 20, 2008, 09:05 PM. Reason: more info to add

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            • #7
              There has been a study on tildren in Europe, I read the paper last week. The paper is called Tiludronate as a new therapeutic agent in the treatment of navicular disease: a double-blind placebo-controlled clinical trial . They found that horses who took tildren spread out over a period of 10 days showed significant improvements. The horses that didn't show any improvement after the first series of doses received a second series and most showed improvement after that. According to the paper "Horses treated with the higher dose showed optimal improvement of lameness and return to normal level of activity 2–6 months post treatment. The more recent the onset of clinical signs at the time of treatment, the greater the efficacy. The treatment did not modify the response to extension and flexion tests. The lower dose failed to significantly improve the condition."

              Tildren limits osteoclast activity, which causes bone degredation. With navicular, the osteoclast/osteoblast ratio is skewed, so the osteoblasts can't form new bone quickly enough to counteract the osteoclasts. So with tildren, the theory is that by limiting/inhibiting osteoclast activity, the osteoblasts can lay down new bone.

              I'm really interested in trying this for my horse. I just wish it didn't cost so much!

              Comment


              • #8
                Originally posted by Aristeia View Post
                Tildren limits osteoclast activity, which causes bone degredation. With navicular, the osteoclast/osteoblast ratio is skewed, so the osteoblasts can't form new bone quickly enough
                Where is the role of osteoclast/osteoblast activity documented discussed or proven as a causative agent of navicular?
                Visit my barefoot blog:
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                "I don't mean to brag, I don't mean to boast, but I'm intercontinental when I eat French toast" ~ Beastie Boys

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                • #9
                  Originally posted by Lookout View Post
                  Where is the role of osteoclast/osteoblast activity documented discussed or proven as a causative agent of navicular?
                  It's not a causative agent of navicular, sorry I wasn't clear on that before. I'll post some of what was said in the paper (which I think is ok to do, university has made me so paranoid about plagiarism...):
                  "Despite the complexity of the disease and its poorly understood aetiopathogenesis, there is converging evidence demonstrating the importance of bone remodelling changes within the distal sesamoid bone in horses diagnosed with navicular disease (Østblom et al. 1982, 1989; Poulos 1983; Pool et al. 1989; Wright et al. 1998). The most prominent changes
                  reported from gross examination, histological and histomorphometric studies are: 1) enlargement of the synovial fossae of the distal border, 2) thickening of the flexor compact bone frequently combined with a decreased compact bone volume due to increased bone porosity in relation with an intense osteoclastic activity and increased osteoid volume suggestive of an increased osteoblastic activity, 3) decreased area of the spongiosa combined with an increased volume of its trabeculae and 4) radiolucent area within the spongiosa surrounded by osseous regions of increased resorption and formation. These changes reflect an increased bone turnover resulting from the increased osteoclastic and osteoblastic activities. The concomitant presence of areas of increased resorption and areas of increased formation is typical of a diseased navicular bone. In that perspective, a parallel can be drawn between a diseased navicular bone and a pagetic bone."

                  "Besides the increased bone turnover, Østblom et al. (1989)
                  demonstrated the uncoupling between resorption and formation in
                  a diseased navicular bone...The difference between both ratios was essentially related to excessive bone resorption in horses with navicular disease. Under such circumstances, bone formation may not be sufficient to replace the resorbed bone. This decoupling between formation and resorption
                  leads to increased bone porosity, bone loss and, possibly, decreased bone mechanical resistance."

                  "Bone remodelling changes are one of the pathological processes induced by the excessive mechanical load of the navicular bone. Tiludronate counteracts this pathological process. By partially inhibiting bone resorption through the
                  inhibition of the osteoclasts, without adversely modifying the osteoblastic activity, tiludronate slows down bone turnover. It helps in restoring a normal balance within a bone subjected to an excessive resorption (Bonjour et al. 1995)."

                  Comment


                  • #10
                    I currently use Arquel for my Navicular horse but was wondering if anyone tried Tildren. A few Questions....

                    1. May I ask what the cost is? My Arquel is about $70.

                    2. Is it legal to show under the USEF?

                    Comment


                    • #11
                      It's not an anti-inflammatory/spot treatment. Cost depends on which type of treatment you do. Some vets are now doing regional profusion of isolated joints for around $200. IV treatment of the whole horse is about $1000.

                      It is legal to show on.
                      "A canter is the cure for every evil."

                      Comment


                      • #12
                        Oh ok now I understand. Thanks for the info. It may be something to look into if eventually our treatments don't work but *knocksonwood* so far so good.


                        Originally posted by BABYGREENTB View Post
                        It's not an anti-inflammatory/spot treatment. Cost depends on which type of treatment you do. Some vets are now doing regional profusion of isolated joints for around $200. IV treatment of the whole horse is about $1000.

                        It is legal to show on.

                        Comment


                        • #13
                          TILDREN

                          I have a 7 year old mare that was recently diagnosed with early navicular. The specialist I took her to wants to do Tildren IV, and shots for the inflamation of the tendons and nerves.She has been lame off and on since 11/07. The lameness has been constant for the last 2 months. It's going to cost me over $1800.00. Is this to much?

                          Comment


                          • #14
                            There are several vets around the country doing studies under the auspices of the USDA. If your horse qualifies for the study, there is no cost to you.

                            But I do not know who is doing studies (or where) in the West.
                            Janet

                            chief feeder and mucker for Music, Spy, Belle and Tiara. Someone else is now feeding and mucking for Chief and Brain (both foxhunting now).

                            Comment


                            • #15
                              I have used tildren twice now. First time on my horse with a bone cyst, with positive results (the IV treament). We are now using for arthritis, but it is still too soon to see results as we just gave him his first dose about a month ago.

                              Comment


                              • #16
                                Originally posted by Janet View Post
                                There are several vets around the country doing studies under the auspices of the USDA. If your horse qualifies for the study, there is no cost to you.

                                But I do not know who is doing studies (or where) in the West.
                                Littleton Large Animal Clinic in Littleton Colorado is doing studies.
                                They might be able to tell you if anyone in AZ is doing a study.
                                Nina's Story
                                Epona Comm on FB

                                Comment


                                • #17
                                  Any updates?

                                  Seeing another 'Tildren' topic, I thought popping this one back up would be OK? I've read the earlier threads, and done some other reading, but I haven't been able to locate anything on long term impact when using this drug.

                                  I have a mildly navicular 9 YO horse, and if using this maybe yearly would be helpful, I'd give it a go. But I'd hate to find that my horse had other issues when he got into his teens, related to this use.

                                  My horse started out barefoot, we've done rads, etc. so I don't need feedback on these items, just wondering if anyone had longer term experience with Tildren, or links for longer term studies.

                                  http://www.vssco.co.uk/docs/TildrenBrochure.pdf
                                  Last edited by learner; Jul. 19, 2008, 05:34 PM. Reason: Adding links on topic

                                  Comment


                                  • #18
                                    I also have wondered about the long term effects of Tildren in horses. I have read that they have used Tildren for over ten years in France now. Does anyone know of a horse that was treated a long time ago? Any long term side effects? I would love to know how the horses treated many years ago in France are doing. My gelding has navicular and I'm definitely considering Tildren.

                                    Comment


                                    • #19
                                      Originally posted by Janet View Post
                                      There are several vets around the country doing studies under the auspices of the USDA. If your horse qualifies for the study, there is no cost to you.

                                      But I do not know who is doing studies (or where) in the West.
                                      Alamo Pentado horse hospital, Buelton CA- for navicular only i believe. but will do the prelim. tests for free to diagnos if your horse qualifies which for some who dont know exactly whats going in there is great.
                                      "If you were doing it wrong I would say something..."

                                      Comment


                                      • #20
                                        There ARE some long term effects starting to emerge (in humans), and... they aren't good. Pretty bad, actually.

                                        I did a search a month or so ago for RAyer's posts on Tildren, and he explains some of the negative side effects. Very helpful. This information made me decide against using Tildren for my horse's fluid-filled bone cyst that was drilled & drained. He is coming along well and the surgeon felt the prognosis was very good (cyst was only 4mmx6mm), but the whole thing is just a bit slow going. The type of cyst he has (caused by trauma) is very rare and there aren't too many documented cases in the world so it's hard to know exactly how long recovery takes, even though things are going well for him so far. In any case, Tildren wasn't my horse's LAST option - it would have just sped up recovery faster. Since it is not his last option, the side effects just weren't worth it to me.

                                        http://www.chronicleforums.com/Forum...en#post3202990

                                        4 posts total by RAyers in this thread - scroll down to read them all.
                                        http://www.chronicleforums.com/Forum...en#post2877376

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