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Chemotherapy-Carboplatin/ Cisplatin

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  • Chemotherapy-Carboplatin/ Cisplatin

    I have a horse that will be receiving Carbolatin injections for a pesky Sarcoid. Has anyone had a horse injected with this? What are the side effects and is there anything I should watch for?
    Last edited by spotnnotfarm; Dec. 27, 2010, 07:57 PM.
  • Original Poster

    #2
    Bumping this up for information on Cisplatin since they are similar medications. Also, how much did the treatment cost.

    Comment


    • #3
      Never used it on horses...but on Dogs we use it as a chemo agent for (usually) osteosarcomas. It is drawn up under a fumehood, with a safe closed system as to prevent any leakage. When given IV in dogs, it is given through an IV catheter, the techs are gowned, gloved and wear masks. Never heard of it being used any other way. You need to be extremely careful when handelling chemo drugs. In dogs, we watch for neutropenia, leukopenia, vomiting and diarrhea. If their wbcs drop they are not given another injection and put in isolation for a few days.

      But, I bet with horses, your vet will inject, pat your horse, and say have a nice day

      Comment


      • #4
        Our then 29 year horse had a very aggressive and fast growing penile tumor, squamous cell carcinoma.
        The vet took off 95% and injected the site with Cisplatin right then and two more times at two weeks intervals.
        The tumor came back twice more, so he had surgery three times and was injected nine times total, over several months.
        After the third time, he was in complete remission, you could not even see where the tumor had been, there was clean, white normal skin there.

        We lost him this summer at 30 from a bad knee.

        Comment


        • #5
          I've had pretty good luck using the Cisplatin beads around melanomas in grey horses (my n is pretty low though, under 30)
          Michael: Seems the people who burned me want me for a job.
          Sam: A job? Does it pay?
          Michael: Nah, it's more of a "we'll kill you if you don't do it" type of thing.
          Sam: Oh. I've never liked those.

          Comment

          • Original Poster

            #6
            Thanks everyone! Were the any side effects? How much did the treatment cost? I have to take him to Auburn University tomorrow and just wondered what to expect.

            Comment


            • #7
              It has been years...maybe 10?... since I had a sarcoid treated with cisplatin injections. I'm really foggy on the details, it has been so long and we treated that sarcoid with everything under the sun, including lasers and surgical removal.

              I had to have a local vet get the cisplatin from the non-local vet that prescribed it, then the local guy came and injected the sarcoid periodically -- once a week? I don't remember! It wasn't terribly expensive, as I recall, for the cisplatin itself - maybe a few hundred bucks. But the call out for the local vet added up ($25 farm call + $40 or whatever he charged to inject, over multiple times).

              In the end, the only thing that removed the sarcoid completely and made it stay away was xterra. After 10 years, or whatever it has been, the sarcoid has finally stayed gone.

              Oh- and no side effects that I noticed, and don't recall being concerned about any.

              Comment


              • #8
                Oh I think the beads were around $100 each our cost (or it was $100 our cost for the pack of three, it's been a while since I've done one) I surgically remove the melanoma and leave the beads behind if there is any doubt about margins or if the melanoma was large.

                As an owner with a melanoma horse it makes me feel better to be "doing something" but as a doc ehhh...I just haven't seen/used enough to be "OOOH we need to do this every time, this is the best method ever" Because of this, we are only charging cost+handling of the beads (no markup) and then the client pays for sedation and surgery etc.
                Michael: Seems the people who burned me want me for a job.
                Sam: A job? Does it pay?
                Michael: Nah, it's more of a "we'll kill you if you don't do it" type of thing.
                Sam: Oh. I've never liked those.

                Comment


                • #9
                  I had a horse treated this summer for sarcoid on her muzzle with cisplatin beads..no side effects that I noticed.
                  sarcoid was treated twice with implants.

                  I think the cost was almost 5,000.
                  save lives...spay/neuter/geld

                  Comment

                  • Original Poster

                    #10
                    Originally posted by fivehorses View Post
                    I had a horse treated this summer for sarcoid on her muzzle with cisplatin beads..no side effects that I noticed.
                    sarcoid was treated twice with implants.

                    I think the cost was almost 5,000.
                    Yikes! I wa told the gas to the University would be more than the treatment! He is just getting an injection not an implant. What did the implants do/look like etc... Did your horse have to stay at the hospital?

                    I am somewhat worried because Grover has a fair amount of allergies and is sensitive to a lot! I am hoping it goes smooth tomorrow and does not have a $5000.00 price tag!

                    Comment


                    • #11
                      beads were 150 each, mare had to go two times, general anesthesia for 15 minutes to implant, 3 day hospital stay x2.
                      cost was 4,300.
                      no, this place isn't cheap, but they are good. But, I do think on the high end of costs.
                      save lives...spay/neuter/geld

                      Comment


                      • #12
                        Dunno about horses but in humans the main side effects of cisplatin/carboplatin: 1. nausea/vomiting - they are the worst offenders of all chemo agents for this 2. drop in platelet counts (like all chemo drugs) 3. drop in white blood cell count (expected - desired - you're attacking their immune system - the biggest drop is about 10-14 days after treatment) 4. damage to kidneys - make sure horse is well hydrated 5. damage to liver 6. hearing loss/ringing of the ears 7. fever (more common with cisplatin than carboplatin).

                        Granted - these are for humans getting high doses for aggressive chemotherapy but it's what I have to offer

                        Comment


                        • #13
                          two horses here were treated only once with the injection of chemo and both had no side effects and the sarcoids nevr came back. Both were done over 4 years ago. The cost was around 200.00 or less at Tufts. No hospital stay, just out patient.
                          Humans don’t mind duress, in fact they thrive on it. What they mind is not feeling necessary. –Sebastian Junger

                          Comment


                          • #14
                            Crest toothpaste is very affective and cheap for most sarcoids.

                            Comment


                            • #15
                              coincidental

                              Hi, all! I haven't been around here for a while, so I was amazed to find this topic that I just emailed my vet about. I've got a mare with a squamous cell carcinoma that I've had standard surgery, laser surgery, and 5-FU chemo on but persists nonetheless. This popped into my mailbox a couple of days ago, and I immediately sent it on to my vet. I had cisplatin treatment myself for cancer, so I know that there are some side effects when it's given IV but nothing to write home about as long as supportive meds are given, and not getting it intravenously has to be better. There was an article about five years ago about cisplatin beads for sarcoids, so the treatment has been around for quite a while. Granted, this article isn't about sarcoids, but the info on the treatment is interesting, and this is the identical tumor that I'm dealing with. I don't have a price estimate yet, but hope to soon. Check this out:

                              http://horseandman.com/medical/cispl...eandman.com%29

                              The side effects of the topical 5-FU were bad enough for me to be unable to finish the 14 days of treatment the first time around, so if this is better, I'm all for it! A single tube of 5-FU was over $300, and that's after the "family discount" at Rite Aid when I made my horse a dependent on their discount program.

                              Comment


                              • #16
                                Originally posted by spotnnotfarm View Post
                                Yikes! I wa told the gas to the University would be more than the treatment! He is just getting an injection not an implant. What did the implants do/look like etc... Did your horse have to stay at the hospital?

                                I am somewhat worried because Grover has a fair amount of allergies and is sensitive to a lot! I am hoping it goes smooth tomorrow and does not have a $5000.00 price tag!
                                The beads we get look like those little plastic cat litter beads, or those little white nonpareils that one puts on cakes or cookies.

                                I would guess the major cost of that $5k bill was anesthesia or surgery charge related.
                                Michael: Seems the people who burned me want me for a job.
                                Sam: A job? Does it pay?
                                Michael: Nah, it's more of a "we'll kill you if you don't do it" type of thing.
                                Sam: Oh. I've never liked those.

                                Comment


                                • #17
                                  Originally posted by rockfordbuckeye View Post
                                  Dunno about horses but in humans the main side effects of cisplatin/carboplatin: 1. nausea/vomiting - they are the worst offenders of all chemo agents for this 2. drop in platelet counts (like all chemo drugs) 3. drop in white blood cell count (expected - desired - you're attacking their immune system - the biggest drop is about 10-14 days after treatment) 4. damage to kidneys - make sure horse is well hydrated 5. damage to liver 6. hearing loss/ringing of the ears 7. fever (more common with cisplatin than carboplatin).

                                  Granted - these are for humans getting high doses for aggressive chemotherapy but it's what I have to offer
                                  Do you have any data about the method of administration? I'm guessing this was IV, but I wonder if they use other methods in people, I'm going to call Dr Mr G and ask if he has a good hospital pharmacist friend with a brain I could pick....oooh I can raid his textbook stash in the den too
                                  Michael: Seems the people who burned me want me for a job.
                                  Sam: A job? Does it pay?
                                  Michael: Nah, it's more of a "we'll kill you if you don't do it" type of thing.
                                  Sam: Oh. I've never liked those.

                                  Comment


                                  • #18
                                    For his penile tumor, our horse was at the vet hospital, either for surgery or for treatments after that, two weeks apart.
                                    Best I remember, each cisplatin injection was around $80 and it was injected directly on the site.
                                    When we hauled him there to be injected, he was lightly tranquilized only, no heavy sedation.

                                    There were no side effects at all locally, no swelling, discomfort or even itching and he never acted sore, slow or quit eating.

                                    Comment


                                    • #19
                                      So, I am a hospital pharmacist with a decent brain

                                      The side effects I stated are (I think I said?) really more for people on IV higher dose for systemic treatment of cancer. So they would be worse case scenario.

                                      I have never seen a human given Sub-Q or IM cisplatin or carboplatin. I looked and there are no papers on it in pubmed. I'm sure someone's tried it but probably for skin tumors and what not and I would likely not see those in the hospital - they would be in outpatient clinics So sorry - no experience!

                                      There are a few regimens that we use other chemo agents in by that route (cytarabine or Ara-C is the most common). In my patients that have had sub-Q cytarabine it is much better tolerated sub-Q vs. IV in higher doses. Which kinda makes sense right? The stuff is basically cell poison and has a very strong dose response curve. Low dose sub-Q isn't going to nearly knock out your immune system like high dose IV would. So I really saw little side effects in patient son sub-q cytarabine, I would totally believe that carboplatin and cisplatin might be as well tolerated.

                                      Comment

                                      • Original Poster

                                        #20
                                        Thanks everyone! We went to Auburn yesterday for his first injection. It was very quick appointment and was not expensive. I asked for banamine since he is sensitive and today there is just a small amount of swelling around the sarcoid. He goes a few more times and hopefully, imporvement will be seen soon!

                                        Comment

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