Stallion Spotlight

Total Hope-11-18-09-3662

Real Estate Spotlight

15159sunnyland18
  • Welcome to the Chronicle Forums.
    Please complete your profile. The forums and the rest of www.chronofhorse.com has single sign-in, so your log in information for one will automatically work for the other. Disclaimer: The opinions expressed here are the views of the individual and do not necessarily reflect the views and opinions of The Chronicle of the Horse.

Announcement

Collapse

Forum rules and no-advertising policy

As a participant on this forum, it is your responsibility to know and follow our rules. Please read this message in its entirety.

Board Rules

1. You�re responsible for what you say.
As outlined in Section 230 of the Communications Decency Act, The Chronicle of the Horse and its affiliates, as well Jelsoft Enterprises Ltd., the developers of vBulletin, are not legally responsible for statements made in the Forums.

This is a public forum viewed by a wide spectrum of people, so please be mindful of what you say and who might be reading it�details of personal disputes may be better handled privately. While posters are legally responsible for their statements, the moderators may in their discretion remove or edit posts, though are not legally obligated to do so, regardless of content.

Users have the ability to modify or delete their own messages after posting. Moderators generally will not delete posts, threads or accounts unless they have been alerted and have determined that a post, thread or user has violated the Forums� policies. Moderators do not regularly independently monitor the Forums for such violations.

Profanity, outright vulgarity, blatant personal insults or otherwise inappropriate statements will not be tolerated and will be dealt with at the discretion of the moderators.

Users may provide their positive or negative experiences with or opinions of companies, products, individuals, etc.; however, accounts involving allegations of criminal behavior against named individuals or companies MUST be first-hand accounts and may NOT be made anonymously.

If a situation has been reported upon by a reputable news source or addressed by law enforcement or the legal system it is open for discussion, but if an individual wants to make their own claims of criminal behavior against a named party in the course of that discussion, they too must identify themselves by first and last name and the account must be first-person.

Criminal allegations that do not satisfy these requirements, when brought to our attention, may be removed pending satisfaction of these criteria, and we reserve the right to err on the side of caution when making these determinations.

Credible threats of suicide will be reported to the police along with identifying user information at our disposal, in addition to referring the user to suicide helpline resources such as 1-800-SUICIDE or 1-800-273-TALK.

2. Conversations in horse-related forums should be horse-related.
The forums are a wonderful source of information and support for members of the horse community. While it�s understandably tempting to share information or search for input on other topics upon which members might have a similar level of knowledge, members must maintain the focus on horses.

3. Keep conversations productive, on topic and civil.
Discussion and disagreement are inevitable and encouraged; personal insults, diatribes and sniping comments are unproductive and unacceptable. Whether a subject is light-hearted or serious, keep posts focused on the current topic and of general interest to other participants of that thread. Utilize the private message feature or personal email where appropriate to address side topics or personal issues not related to the topic at large.

4. No advertising in the discussion forums.
Posts in the discussion forums directly or indirectly advertising horses, jobs, items or services for sale or wanted will be removed at the discretion of the moderators. Use of the private messaging feature or email addresses obtained through users� profiles for unsolicited advertising is not permitted.

Company representatives may participate in discussions and answer questions about their products or services, or suggest their products on recent threads if they fulfill the criteria of a query. False "testimonials" provided by company affiliates posing as general consumers are not appropriate, and self-promotion of sales, ad campaigns, etc. through the discussion forums is not allowed.

Paid advertising is available on our classifieds site and through the purchase of banner ads. The tightly monitored Giveaways forum permits free listings of genuinely free horses and items available or wanted (on a limited basis). Items offered for trade are not allowed.

Advertising Policy Specifics
When in doubt of whether something you want to post constitutes advertising, please contact a moderator privately in advance for further clarification. Refer to the following points for general guidelines:

Horses � Only general discussion about the buying, leasing, selling and pricing of horses is permitted. If the post contains, or links to, the type of specific information typically found in a sales or wanted ad, and it�s related to a horse for sale, regardless of who�s selling it, it doesn�t belong in the discussion forums.

Stallions � Board members may ask for suggestions on breeding stallion recommendations. Stallion owners may reply to such queries by suggesting their own stallions, only if their horse fits the specific criteria of the original poster. Excessive promotion of a stallion by its owner or related parties is not permitted and will be addressed at the discretion of the moderators.

Services � Members may use the forums to ask for general recommendations of trainers, barns, shippers, farriers, etc., and other members may answer those requests by suggesting themselves or their company, if their services fulfill the specific criteria of the original post. Members may not solicit other members for business if it is not in response to a direct, genuine query.

Products � While members may ask for general opinions and suggestions on equipment, trailers, trucks, etc., they may not list the specific attributes for which they are in the market, as such posts serve as wanted ads.

Event Announcements � Members may post one notification of an upcoming event that may be of interest to fellow members, if the original poster does not benefit financially from the event. Such threads may not be �bumped� excessively. Premium members may post their own notices in the Event Announcements forum.

Charities/Rescues � Announcements for charitable or fundraising events can only be made for 501(c)(3) tax-exempt organizations. Special exceptions may be made, at the moderators� discretion and direction, for board-related events or fundraising activities in extraordinary circumstances.

Occasional posts regarding horses available for adoption through IRS-registered horse rescue or placement programs are permitted in the appropriate forums, but these threads may be limited at the discretion of the moderators. Individuals may not advertise or make announcements for horses in need of rescue, placement or adoption unless the horse is available through a recognized rescue or placement agency or government-run entity or the thread fits the criteria for and is located in the Giveaways forum.

5. Do not post copyrighted photographs unless you have purchased that photo and have permission to do so.

6. Respect other members.
As members are often passionate about their beliefs and intentions can easily be misinterpreted in this type of environment, try to explore or resolve the inevitable disagreements that arise in the course of threads calmly and rationally.

If you see a post that you feel violates the rules of the board, please click the �alert� button (exclamation point inside of a triangle) in the bottom left corner of the post, which will alert ONLY the moderators to the post in question. They will then take whatever action, or no action, as deemed appropriate for the situation at their discretion. Do not air grievances regarding other posters or the moderators in the discussion forums.

Please be advised that adding another user to your �Ignore� list via your User Control Panel can be a useful tactic, which blocks posts and private messages by members whose commentary you�d rather avoid reading.

7. We have the right to reproduce statements made in the forums.
The Chronicle of the Horse may copy, quote, link to or otherwise reproduce posts, or portions of posts, in print or online for advertising or editorial purposes, if attributed to their original authors, and by posting in this forum, you hereby grant to The Chronicle of the Horse a perpetual, non-exclusive license under copyright and other rights, to do so.

8. We reserve the right to enforce and amend the rules.
The moderators may delete, edit, move or close any post or thread at any time, or refrain from doing any of the foregoing, in their discretion, and may suspend or revoke a user�s membership privileges at any time to maintain adherence to the rules and the general spirit of the forum. These rules may be amended at any time to address the current needs of the board.

Please see our full Terms of Service and Privacy Policy for more information.

Thanks for being a part of the COTH forums!

(Revised 5/9/18)
See more
See less

Isoxsuprine Shortage

Collapse
X
  • Filter
  • Time
  • Show
Clear All
new posts

  • Isoxsuprine Shortage

    HELP!!! Smartpak is out of Isoxsuprine 20mg. They have serviced my supplements for Cruise for three years, and out of no where, they are out. I have searched everywhere....can't find the stuff. Anyone know what is going on with this drug, and where, if anywhere, it can be purchased at?

    My boy needs daily dosing on this, and I dont know what my alternatives will be if I can not locate some asap. Any info/advice much appreciated. Thanks.
    Esmarelda, "Ezzie" 1999 Swedish Warmblood

    "The world is best viewed through the ears of a horse."

  • #2
    I haven't used it in awhile, but when I was having trouble getting the liquid form a few years back, my vet was able to obtain it via a compounding pharmacy. You might check with your vet to see what they can do. I'll be curious if others have had any issues lately. It was suggested for my founder horse a few months back, and no mention was made of a shortage then, but perhaps that has changed recently.

    Comment


    • #3
      it looks like heartland vet has powder and liquid suspension available, just the pills are currently unavailable. They are a reputable organization, I generally order all my scrip drugs through them.
      Your crazy is showing. You might want to tuck that back in.

      Comment


      • #4
        I have a brand new bottle at the barn. Let me check to see what the mg are. My trainer picked it up for my horse why I don't know, we don't use isox! let me know if you are interested.
        Last edited by Jacqui; Dec. 17, 2010, 11:14 AM. Reason: spelling

        Comment


        • #5
          *bumping this up*

          I just called my vet to get some more isoxsuprine for my navicular horse, and she told me I was getting her very last bottle -- and that as far as she knows, it is out of production in the U.S. now. So, I came here to COTH to search on "isoxsuprine" and see if anyone else had heard about this? A Google search on the drug in general seems to confirm that it's been withdrawn from the U.S. market. My vet's office is looking into whether or not they can compound it as a powder, and what that might cost. Has anyone heard WHY isoxsprine has been withdrawn?

          Comment


          • #6
            No idea of the why, but I have a friend with a horse on it, and she was told it was backordered from the manufacturer, and was given the liquid compounded by Wedgewood. It's quite a bit more expensive, like 3-4x as expensive, IIRC (but that is getting it via her vet).

            Comment

            • Original Poster

              #7
              Smartpak was able to supply me with isoxsuprine powder, flavored as well. Im not sure how he will like it, as it is set up for my next shipment. He hates all powders....so if this doesnt work, its off the the phamacy to have it compounded.
              Esmarelda, "Ezzie" 1999 Swedish Warmblood

              "The world is best viewed through the ears of a horse."

              Comment


              • #8
                It's on maufacturer back order

                Comment


                • #9
                  It's on backorder. We can get it sporadically, but there is no guarantee. Once we are out, we'll be ordering it compounded for our clients.

                  Don't worry, anyone with a horse on Metronidazole? That one is having issues too, and our price went up about 400% for a bottle. It's costing us roughly $230 for a bottle of the stuff. So, don't be too surprised if you need more, and it's outrageously expensive.

                  Comment


                  • #10
                    I have a bottle of metronidazole which I bought for use if any horse needed it. It was, I think 150$ a year or so ago.

                    I had a bottle of isox last summer but used it all at vet's direction.

                    And terramycin, it went up too. I was told by a catalogue supplier for horses that the pfizer lab had closed down and that it was on backorder. Something happened at the lab to cause it to be shut down. Makes me wonder what problems they were having and if any of the meds got tainted.

                    Comment


                    • #11
                      I've yet to read a single study that showed oral isox had any effect in the treatment of "navicular". Even if it did improve blood flow (which unless you're using it IV it doesn't), lack of blood flow to the area has never been shown as a cause of navicular syndrome in horses.

                      J Vet Pharmacol Ther. 2002 Apr ;25 (2):81-7 12000527 Cit:2 Isoxsuprine hydrochloride in the horse: a review.[My paper] R S Erkert, C G Macallister
                      Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.

                      Isoxsuprine hydrochloride has been suggested for use in horses for treatment of navicular syndrome and laminitis. The drug has been shown to be a beta-adrenoreceptor antagonist with beta-adrenoreceptor agonistic properties, with both characteristics contributing to vasodilation and uterine relaxation. In addition, the drug is capable of decreasing blood viscosity and platelet aggregation. Studies have shown i.v. isoxsuprine to have a plasma half-life of <3 h with a large apparent volume of distribution. Cardiovascular effects resolve rapidly following i.v. administration, but are absent with oral dosing. Oral bioavailability is 2.2% with a high first pass effect. Isoxsuprine has an apparent affinity for melanin that may contribute to extended renal excretion. Clinical trials appear to support the use of isoxsuprine for treatment of navicular disease. However, poor bioavailability, lack of cardiovascular effects following oral administration, superficial support in clinical trials, and new evidence regarding the pathogenesis of navicular syndrome indicate that the use of isoxsuprine for treatment of navicular syndrome or laminitis is questionable at best.

                      Comment


                      • #12
                        I wondered how long it would be before a thread about the lack of availability of isoxsuprine would attract a "it don't work!" post. It took much longer than I thought.

                        Comment

                        • Original Poster

                          #13
                          Originally posted by rcloisonne View Post
                          I've yet to read a single study that showed oral isox had any effect in the treatment of "navicular". Even if it did improve blood flow (which unless you're using it IV it doesn't), lack of blood flow to the area has never been shown as a cause of navicular syndrome in horses.

                          J Vet Pharmacol Ther. 2002 Apr ;25 (2):81-7 12000527 Cit:2 Isoxsuprine hydrochloride in the horse: a review.[My paper] R S Erkert, C G Macallister
                          Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.

                          Isoxsuprine hydrochloride has been suggested for use in horses for treatment of navicular syndrome and laminitis. The drug has been shown to be a beta-adrenoreceptor antagonist with beta-adrenoreceptor agonistic properties, with both characteristics contributing to vasodilation and uterine relaxation. In addition, the drug is capable of decreasing blood viscosity and platelet aggregation. Studies have shown i.v. isoxsuprine to have a plasma half-life of <3 h with a large apparent volume of distribution. Cardiovascular effects resolve rapidly following i.v. administration, but are absent with oral dosing. Oral bioavailability is 2.2% with a high first pass effect. Isoxsuprine has an apparent affinity for melanin that may contribute to extended renal excretion. Clinical trials appear to support the use of isoxsuprine for treatment of navicular disease. However, poor bioavailability, lack of cardiovascular effects following oral administration, superficial support in clinical trials, and new evidence regarding the pathogenesis of navicular syndrome indicate that the use of isoxsuprine for treatment of navicular syndrome or laminitis is questionable at best.
                          Well, i have used this on my horse for 5 years, per the advice of my veterinarian...and he is still sound, and being ridden because of it. It works for me. Every horse is different, and so is everyone's opinion. This thread was just to help me locate the medication, not to degrade or argue its effectivness.
                          Esmarelda, "Ezzie" 1999 Swedish Warmblood

                          "The world is best viewed through the ears of a horse."

                          Comment

                          Working...
                          X