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question about the one nsaid rule...

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  • question about the one nsaid rule...

    Anyone know how much previcox falls into the one nsaid rule? I briefly read the usef website but I wasn't sure of the answer.

  • #2
    It *is* an NSAID by all definitions, but that doesn't mean the USEF rules aren't a confusing mess! The drugs & meds people are generally very quick to answer emails and get right to the point about questions like this.
    Click here before you buy.


    • Original Poster

      Thanks Deltawave! I guess I mean is how much previcox falls under the one nsaid rule. Bute is easy. One tablet. Previcox or Equioxx, 1 57 mg tablet, or one 227 mg tablet or one tube of Equioxx? I did try to sift throught their website tonight and found a press release on Cox-2 inhibitors but not a lot of "useful" info. I guess I will try emailing them in the morning to see what they consider the 1 nsaid equivelent of previcox.


      • #4
        One tube of Equioxx is the normal dose, so I assume that is allowed. However, I am assuming that. The more important issue here is that Previcox is not legally prescribed for horses, so I'm not surprised that they don't list the dosage. The vet that gave you Previcox for your horse is a risk of being fined for off-label use, and they are going after vets for this. So be careful!
        \"I refuse to engage in a battle of wits with someone who is unarmed.\"--Pogo


        • #5
          From the rules:
          Firocoxib (Equixoxx as brand name): 0.1 mg/kg (0.0455 mg/# or 45.5 mg/1000#) >12 hr prior to competition Orally only.

          From the Product label
          When give as labeled, the dose is as above.
          Each mark is for 250# (at above dose) and each notch is for 50#. Then entire sryinge treats a 1250# horse at the above dose.

          So it is pretty simple and straightforward.

          As for using Previcox vs Equioxx...
          The testing detects the active drug, ie firocoxib. It doesn't matter the brand name source.
          However, the pharmacokinetic data is from the paste formulation only. Actually it reads: "When administered at a 0.045 mg/# dose in oral paste to adult horses with normal access to roughage, feed and water the absolute bioavailablity of firocoxib from Equioxx paste is approximately 79%." I don't think there are any studies looking at the bioavailablity of firocoxib in the tablet from, ie Previcox.
          Bioavailability is the amount of the compound that actually gets into the blood after is given and is affected by its break down in the GI tract, the ability of its chemical structure to be transported across or be absorbed across the intestinal lining and how much is degraded by the liver. The formulation of how the active drug is mixed with ingredients to administer affect the first one, and to some degree the second one. This is how some drugs are extended release, continuous release, or immediate release. Like the extended release formulation of Ambien--it has 2 formulation of the active drug; one is available right away so you get an immediate effect from it and the other is mixed with compounds that allow it be more slowly absorbed from the GI tract to allow a slow trickle in the blood stream to keep the blood level steady.
          Different species can handle the same drug, and formulaiton of it, differently. Previcoxx has been formulated so that it is metabolized by a carnivore. Equioxx is formulated to be metabolized by a herbivore. Some times this makes a difference in drug handling by the body. Sometimes it doesn't. Another good example is aspirin and tylenol in cats vs dogs, even both are carnivores. Aspirin is metabolized by the dog very much like it is in us. However cats lack an essential enzyme in their liver to metabolize it so it lasts a much longer time. About 3 days vs 8-12 hrs. Tylenol in the dog is very much like in people. Cats cannot metabolize it at all and actually convert it to a toxic substance. Or bute in horses vs dogs vs people. Horses tolerate it very well, dogs not so well, people hardly at all. This may be due to how they metabolize the drug (other reasons too).

          So, while the drug test cannot tell whether the firocoxib came from the Equioxx paste or the Previcoxx tablet, the amount in the horses blood from a 45.5 mg dose of the paste may be different from the amount in the blood from a 45.5 mg tablet.

          There you have it.


          • #6
            You might want to post in the h/j forum as I know its a popular drug & many posters over there use it. Might even encounter one that was drug tested. I've used it 12hrs out but never been tested.


            • #7
              The recommendation I got was to give 3 of the 57 mg tabs as a loading dose, and then give one tab in the PM feed daily (so 12 hours before the horse competed). This was for the T3D--I gave the loading dose the night before leaving for the competition, and then gave one tab each on move-in day, dressage day, xc day, and sj day. But my horse was not tested.