We've had great success with Marquis down here. We have had the myriad of symptoms and lack there of in the horses as well. One horse showed the neuro signs first and was treated, though the titer didn't show that he had it. Another had muscle atrophy but neuro was okay, test showed he had it.
I also understand that even if the tests show that the horse does not have EPM, but fails the neuro test, it's still pretty likely the horse has EPM. Or that it shouldn't be ruled out as a possibility.
Well I am in the middle of the EPM battle as well. 5 yr old APHA mare, that in August tested with SAG titers of 8,4,8....she'd been being treated for several months for a severe ear infection with SMZ. She's never had any neuro signs, slight head tilt and twitch from time to time, but 100% stable on her feet. Have had her on Marquis, gastrogard, 10,000 IUI of Vitamin E and 10,000 mg of MSM for 5 weeks now, re-did her blood work yesterday. SAG came back higher, now she's has a 16,4, 32 (one 1, 5 and 6). So I am switching to Oroquin 10.
We had planned to do a spinal tap, then in a freak stall accident two days before her appointment last month, she suffered a fracial and sinus cavity fracture, so she can't even have a halter on her her head, much less be trailered or put in stalks.
She's my 5 yr old son's best friend and the kindnes mare around, we are taking it one day at a time, but this sure is an awful disease.
My day 5 update on Oroquin 10.....my mare had been on marquis for 5 weeks and her symptoms starting coming back, re-did the Elisa test and her SAG numbers trippled...so I switched her to the Oroquin 10, the difference in only 5 days in incredible. She's never been super neuro, but she had a head tilt and twitch, eye blinking, soft tail pulls, etc. She looks remarkable. I've video's her entire journey since Feb of this year and finally posted all the video's on youtube to document. Dr.E is using her a test horse, in fact my son and her are on her blog right now. If anyone is intersted in seeing the video updated, drop me a PM. So far I am thrilled with the improvement.