Noticeable difference? What schedule did you use after the four weekly shots? Did oral joint supplements help as much as the Pentosan? Continuing oral sups after?
My 27 yr. old will be starting Pentosan next week. He's always had decent joint supplements but vet feels this will make a big difference. He's not crippled, but compensating for his right hock. I'm hoping it'll feel like a total body overhaul.
Do you give the shots yourself? I'm a huge wuss when it comes to even seeing a syringe and have never given a shot before. I'm hoping I can barter with a boarder to give the shot in exchange for some bodywork on her horse.
I've been very pleased with the results. For my horse, it has proved to be far more effective than any oral supplement and even better than Adequan.
(My horse has a fusing right hock that causes him some problems. He's been on it since last June and one thing it has allowed us to do is to not have to do IA injections with any frequency.)
It took until the third loading dose to see a dramatic improvement. My vet generally says 6-8ml every 4 weeks after the loading period. However, mine is a big horse and we have found that 4ml every 2 weeks works best for him.
I do my own IM injections. If you are going to do so, spend the few cents extra to buy better quality needles and syringes--or get them from your vet. It makes everyone's life much happier if the needle is really sharp and the syringe doesn't stick!
Get the vet to show you how, then practice on an orange until it doesn't wierd you out any more.
I get it from Wedgewood Pharmacy. Yes, it's perfectly legal. Really. The gubmint is not going to come and git you for giving it to your horse.
Adequan can't hold a candle to this stuff. I've got a 20 year old draft cross that went from creaky/sore/grouchy old man back to playing hard, including rearing, with his pasture buddies. He got his mojo back out hunting, too. (which is not necessarily a good thing if you haven't bitted up!)
Doesn't hurt to try the drug, and if it works well for your horse he's going to be much more comfortable at rest and in work.
Brothers and sisters, I bid you beware
Of giving your heart to a dog to tear.
I know with my generic Immitrex for migraines, all generic brands are not created equal, and this is by my own experience.
It's also fair to say that not all *people* are created equal, because the variable response to various brands of drugs is well documented to be an individual-person thing much more so than an individual-drug thing.
I use generic Imitrex and find it just exactly as effective as the brand name, and this includes 3 different generics over the years.
The amount of variation between prescription drugs is legally not allowed to be anything more than infinitesimal. That's NOT to say that certain people don't respond better to certain brands, but again that is more of a difference in human beings than it is a difference in drugs.
I get Pentosan from Abba Vet. It is, however, labeled from Wedgewood so that is where it is made/compounded. I haven't had a horse under saddle to try it on yet--the one I plan to use it for is still a few weeks away from riding but I plan to use it on him--rehabbing from a neck injury. My trainer uses it sort of "prophylactically" on her Prelim horse who has no particular problems and thinks it helps keep him loose and supple.
I have done A LOT of research on Pentosan the last few months since Adequan was not working for my guy, nor was hock injections. "Sodium pentosan polysulfate" is available from compounding pharmacie in the US legally. The company that makes "Pentosan Equine" have not paid the *big bucks* to have it FDA approved over here (& you guys thought it was about health?), hence going through a Compounding Pharmacy is the way to go in the US. Unfortunately a lot of vets don't know about Pentosan, probably because they are not getting any marketing material on it.
Pentosan has been used medicinally for over 50 years, and not just for horses, people too. Here is a link to a small free e-book written by Linda Curreri called "PENTOSAN POLYSULPHATE, A MEDICINE MADE FROM BEECH BARK". It is 50-something pages, but well worth the read. I'm giving my vet a printed copy this weekend.
I ordered mine online & have given my horse 3 injections and I'm noticing improvement already. I am also giving him Adequan since the two work very well together in healing the joint tissue. Very excited since Adequan on its own & hock injections did nothing at all.
We have a 12 yr old OTTB who raced till 5 1/2 yrs w/ 30-some starts. He has a slightly toed-in L front w/ small fetlock "jewelry". He has a bit of a weak R stifle too. He events at Training planning to go Prelim late summer. We have always tried to preemptively help him stay sound w/ different products. He has had joint injections in the hocks and R stifle.
We have always had him on MSM--it is easy to give and cheap. I'm not much of a believer in oral supplements other than MSM. When he was 8 yrs old, we put him on Adequan. Loading dose and monthly. We never really saw a huge difference but wanted to be proactive.
Last year after reading many threads here on COTH about Pentosan, I decided to ask the vet what he thought. He did not have much knowledge of Pentosan but was willing to give it a try. He wrote me a prescription for Pentosan and I got it from Wedgewood pharmacy.
I gave it in a loading dose (I give the IM injections myself) and noticed around week 3-4 the horse seemed less stiff and more flexible. He has been feeling better and better. We give him 6 cc every 3 weeks. The Pentosan has helped make the joint injections "last" longer. It has been over a year since we injected his hocks and was at the vet April 2nd for a pre-show season checkup, and he flexed great on both hocks. He used to get hock injections about every 8 months.
I am now a real believer in Pentosan. Our horse has never felt better and he is going much better even with more difficult work.
I started using it last year on my then-18 yo after my vet recommended it. She has been having a lot of luck with it. My guy just has some minor hock arthritis that joint injections didn't seem to help. The penotsan made a huge difference. Much more fluid and comfortable. We did a weekly shot for 4 weeks in mid-summer and he is now in the 2nd week of his second regimen. My vet finds many horses only need it once or twice a year. I love it!