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  1. #1
    Join Date
    Apr. 21, 2010
    Location
    Richlands, NC
    Posts
    66

    Talking Great News! NEW EPM Medication! 10 day treatment!

    Hey Everyone, please feel free to contact me for info. and feel free to cross post!

    One of my LOVELY 5 yo TB mares came down with Sudden Onset EPM on Thursday. She is extremely wobbley in her hind-end. My vet did blood work and we decided to over-night Marquis to start her on treatment.

    I am a trained EPIDEMIOLOGIST or an "outbreak" specialist. My sister told me of a new treatment for EPM. I asked my vet about it and she found out that it is not federally approved yet BUT they are doing a research trial. I called the company and they accepted my mare, Emma, into the field trial.

    They have had HUGE success with this product. Over 96% completly healed in 10 days with the other 4 % doing well with an immune booster.

    The medication is on it's way! I will keep everyone posted on the results.

    The company also wants to work with me to do research on EPM.

    I am so relieved to find this product. I had to share!

    When it is federally approved it will cost only 150 dollars for the treatment and does not have the side effects of the current meds.

    A true miracle!
    Heidi A. Lord
    Fast First Farm Richlands, NC
    Facebook: fastfirstfarm


    1 members found this post helpful.

  2. #2
    Join Date
    Dec. 22, 2010
    Posts
    146

    Default

    Is the "new" drug Levamisole?



  3. #3
    Join Date
    Apr. 21, 2010
    Location
    Richlands, NC
    Posts
    66

    Default

    It is called OROQUIN-10
    Heidi A. Lord
    Fast First Farm Richlands, NC
    Facebook: fastfirstfarm



  4. #4
    Join Date
    Dec. 22, 2010
    Posts
    146

    Default

    From the Pathogenes website:

    Oroquin-10 is a highly effective anti-coccidiocidal drug compounded with an immune stimulant, Levamisole. The quinalone drug kills intracellular protozoa more rapidly and at a lower dose than conventional agents used to treat EPM by targeting protozoan mitochondria. In vitro cell assays determined that S. neurona and Neospora hughesi are eliminated at one tenth the dose of other coccidial agents used in EPM. The oral compound begins killing within 1 day. A prevention stratagy can be used to eliminate chronic relapsing EPM at 1/100th the costs of conventional therapy....


    1 members found this post helpful.

  5. #5
    Join Date
    Apr. 21, 2010
    Location
    Richlands, NC
    Posts
    66

    Default

    They only use the immune stimulant in less than 4 % of the cases.

    I am excited to be part of this trial and hope it will help other horses.

    Sounds like you are not a proponent, any reason why?
    Heidi A. Lord
    Fast First Farm Richlands, NC
    Facebook: fastfirstfarm



  6. #6
    Join Date
    Dec. 22, 2010
    Posts
    146

    Default

    I see. Honestly, I am all for ANYTHING that helps EPM horses . Such a frustrating difficult disease....Just curious about the "New" part of the statement, since Levamisole is not really new, but sort of 'reworked'. I hope it helps!



  7. #7
    Join Date
    Jan. 16, 2002
    Location
    West Coast of Michigan
    Posts
    36,321

    Default

    Oh Lord, not another Oroquin thread! Please?

    How much did you have to pay to be included in the (non-randomized, non-peer-reviewed, non-blinded) "trial"?

    Extremely promising, but being handled (IMO) VERY badly by people that are clearly very passionate but (IMO) are forcing this through before the actual data are there in (IMO) a very non-ethical manner.
    Click here before you buy.



  8. #8
    Join Date
    Apr. 21, 2010
    Location
    Richlands, NC
    Posts
    66

    Default

    I do not get why people are so negative. Ugh...I have a PHD in this stuff! AND..there is NO CHARGE! JUST send blood for their research.

    I am happy to help other horses and I am looking toward to sharing the results.
    Heidi A. Lord
    Fast First Farm Richlands, NC
    Facebook: fastfirstfarm



  9. #9
    Join Date
    Feb. 6, 2000
    Location
    MA
    Posts
    12,917

    Default

    Levamisole may not have the same side effects as "current meds", but it does have side effects of its own...
    "It's like a Russian nesting doll of train wrecks."--CaitlinandTheBay

    ...just settin' on the Group W bench.



  10. #10
    Join Date
    Apr. 21, 2010
    Location
    Richlands, NC
    Posts
    66

    Default

    I am willing to take the risk based on the current stats. And hope it will help others in the future.

    I will update after treatment!
    Heidi A. Lord
    Fast First Farm Richlands, NC
    Facebook: fastfirstfarm



  11. #11
    Join Date
    Jan. 16, 2002
    Location
    West Coast of Michigan
    Posts
    36,321

    Default

    People who are scientists have a healthy respect for the scientific method, which does not permit skipping steps or making gigantic leaps of faith. Passion has its place in the pursuit of new treatments, but it can't be allowed to blind a researcher into taking short cuts and calling it proper science.

    The players in this case seem (IMO!) to be putting the cart before the horse and taking this product to the public before the work is done.
    Click here before you buy.



  12. #12
    Join Date
    Jan. 16, 2002
    Location
    West Coast of Michigan
    Posts
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    Default

    So with a PhD in Epidemiology, how impressed are you by the statistical methods being used in "studying" this drug? With the study design? The placebo arm? The robustness of the database to date?

    Because although my advanced degree is not in epidemiology specifically, I am completely unimpressed by all of the above and think it is rather bad science, to be honest. Maybe the drug IS marvelous and a godsend-in-the-making, but they sure are going about it in an odd way.

    I've had a horse with EPM, too. It sucks right out loud. The temptation is almost too massive to be resisted to use "anything" that might even promise to help. But as an epidemiologist, you realize this is not the way to base a hypothesis, yes?
    Click here before you buy.


    1 members found this post helpful.

  13. #13
    Join Date
    Apr. 21, 2010
    Location
    Richlands, NC
    Posts
    66

    Default

    It is a research drug and not federally approved. But again, based on the stats, I am happy to be a small part in this research. Not unethical as it is fully disclosed. BTW: They also do HUMAN clinical trials. This is the same.
    Heidi A. Lord
    Fast First Farm Richlands, NC
    Facebook: fastfirstfarm



  14. #14
    Join Date
    Jan. 16, 2002
    Location
    West Coast of Michigan
    Posts
    36,321

    Default

    Did you sign a disclosure and informed consent? Genuinely curious. I have great reservations about their "stats", personally, but to each their own. I wish they had done a LOT more preliminary work before bringing this right out and selling it as a NEW EPM Medication! I also have a BIG problem with the claim that the drug is "non toxic to animals".

    Maybe in theory this is "the same" as a human phase I or II clinical trial, but unless there is a LOT more documentation, validation of specific diagnosis, use of control groups, etc. I would argue that the attempt here is not even close. Is there, perhaps, a lot more robust paperwork/consent/diagnostic data included for those who are actually participating?
    Click here before you buy.



  15. #15
    Join Date
    Feb. 6, 2000
    Location
    MA
    Posts
    12,917

    Default

    BTW, you *do* realize that the website in your sig is a dead link, don't you?
    And no, this is emphatically *not* the "same" as human clinical trials.
    It appears to be self-selection on the part of participants.
    "It's like a Russian nesting doll of train wrecks."--CaitlinandTheBay

    ...just settin' on the Group W bench.



  16. #16
    Join Date
    Mar. 8, 2004
    Location
    Baltimore, MD
    Posts
    20,551

    Default

    Just curious, do they pay you guys to come on here and tout the stuff as the next miracle? Give it to you free? It has been pushed down our throats so hard it is having the opposite effect on me. I feel if they have to go to these lengths to get the word out it must be bunk. COTHers are pretty savvy, if there is something novel that is legit we will find it and spread the word on it's own merit. Not some greenie screaming from the rooftops. FYI stating your credentials in the OP casts doubt as well. If it really were that good who cares what you do for a living?



  17. #17
    Join Date
    May. 21, 2008
    Posts
    76

    Default

    Good Luck! Hope it works for your horse. If it doesn't, you might take a look at a product called Sefacon--I've had excellent results on 3 different horses, with no problems relapsing--on any of the horses. Easy 10-day treatment (not as cheap as this stuff, but $200 cheaper than Marquis, and as I said, no relapsing).

    www.endocrinetech.com/html/sefacon.htm



  18. #18
    Join Date
    Mar. 14, 2010
    Location
    Earlysville, Virginia
    Posts
    3,271

    Default

    Wow, did the company give you the drugs in exchange for advertising? The coth community isn't stupid. Sorry.
    Charlie Brown (1994 bay TB X gelding)
    White Star (2004 grey TB gelding)

    Mystical Moment, 1977-2010.



  19. #19
    Join Date
    Jun. 7, 2002
    Location
    Virginia
    Posts
    3,683

    Default

    Here we go again. I'm "chasing down" my PhD currently and I find it surprising that:
    1. You don't know how to "spell" PhD,
    2. You're completely unconcerned with the scientific method, and
    3. You begin an inflammatory thread complete with block caps and multiple exclamation points in the title.

    It's also interesting that your first post and your diction are a little familiar. I'm having a very difficult time believing that an epidemiological expert would have this "science be damned" attitude, not to mention the naive tone of your posts doesn't jive with who you claim to be.
    "Absent a correct diagnosis, medicine is poison, surgery is trauma and alternative therapy is witchcraft" A. Kent Allen
    http://www.etsy.com/shop/tailsofglory


    1 members found this post helpful.

  20. #20
    Join Date
    Jun. 7, 2002
    Location
    Virginia
    Posts
    3,683

    Default

    OP, for your reference just in case you're on the up and up:

    http://www.chronofhorse.com/forum/sh...&highlight=epm

    http://www.chronofhorse.com/forum/sh...&highlight=epm


    What is your specific area of expertise? Where was your degree conferred? Have you had anything published? If I'm wrong here, you have my sincerest apology, but it looks to me like you're a full time trainer/owner of Fast First Farm in North Carolina. All the BS surrounding Oroquin-10 has left me sensitized to those trying to add ingredients to the $h!t soup.
    Last edited by JackieBlue; Mar. 18, 2012 at 12:43 AM.
    "Absent a correct diagnosis, medicine is poison, surgery is trauma and alternative therapy is witchcraft" A. Kent Allen
    http://www.etsy.com/shop/tailsofglory



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