I have only used ulcer guard and have loved it. I own to TB's that came with ulcer's so I have to be really careful. My vet suggested one dose of ulcerguard and also to eat alfalfa hay on the trip. The theory of the alfalfa is to keep the calcium level high in the stomach. so far it has worked well and I'm shipping around short hauls and long hauls at least once a week. so far no new ulcers.