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  1. #1
    Join Date
    Mar. 31, 2006
    Posts
    281

    Default Pergolide vs. Starving Help!!!!

    I acquired an older mare about 6 months ago. She came to me with a Cushings diagnosis, as well as her supply of pergolide. Oral, "apple-flavored" powder, 1 mg dosage. Her previous owner sprinkled the dosage on her feed and she would pick at her feed. She was on a generic mill-mixed, corn looking feed that she didn't care for on a good day. I weaned her off of her old food and moved her into my feeding program.

    If I add her pergolide to her feed, she will not eat. For days. I have tried 4 different feeds. I have tried to hide her meds in cored apple pieces. Pears. Bananas. Jelly sandwiches. Peanut butter sandwiches. Apple sauce. Jelly. Pergolide cookies. (a sample from the vet.) She will not eat her hidden meds, then she will not eat her feed. She grazes very well. She works on her hay in her stall at night. Her weight is OK, but, I am worried.

    Giving her dosage as a liquid I just don't think is an option as she practically puts me into next week when its worming time. I can't imagine it daily. Plus, this old gal is really good at spitting.

    I'm going to have the vet out, but, I really don't know what to do. I understand the risk of her not being on her meds, but, I don't know how to get it into her. Help!!



  2. #2
    Join Date
    Jun. 30, 2006
    Location
    SF Bay Area, California
    Posts
    5,179

    Default

    I'm sure you will get some great advice from people here who understand Cushings, but I do know there is a Yahoo Group dedicated to Cushings and I understand the group is quite popular.
    Proud owner of a Slaughter-Bound TB from a feedlot, and her surprise baby...!
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  3. #3
    Join Date
    Oct. 25, 2007
    Posts
    3,580

    Default

    My horse who has cushings, and gets 1 mg a day of pergolide also has a problem with it.
    He gets a powdered apple flavor too. I just put it in his triple crown senior, shake so it distrubutes and give it to him at night. He might not eat it right away, but by morning it is gone.

    In the beginning, he would go off feed, so I'd stop for a week or two until he was eating his grain, then slowly add a pinch and gradual add up to full dose.

    He has been on pergolide now for at least 5 years, and the first couple I had to stop and restart a few times.
    save lives...spay/neuter/geld



  4. #4
    Join Date
    Jul. 25, 2007
    Location
    Arizona
    Posts
    1,026

    Default

    My mare is extremely fussy too! What works for me is shoving a capsule in her mouth (along the side where there are no teeth )while she is chewing on a treat. The capsule sticks in her mouth and there is just no spitting it out.



  5. #5
    Join Date
    Apr. 22, 2006
    Posts
    1,331

    Default

    I've got another one that won't eat anything with powdered pergolide on it, no matter what flavor it is. I found that the alfalfa flavored Gourmeds (from Wedgewood Pharmacy) along with a small scoop of alfalfa pellets added to his regular senior worked. It's been several months now (knock on wood) with no issues. I think the alfalfa flavor is close enough to the alfalfa pellets that he doesn't get alerted to the difference. I don't dare try it without the pellets. This is the only combination that has worked for me. It's economical too. My vet wrote me a prescription for 2 mg. I break them in half and 30 Gourmeds last 2 months. The 30 Gourmeds are only $54, so it comes out to $27 a month.
    Last edited by ptownevt; Dec. 13, 2010 at 08:09 PM. Reason: grammar
    "The captive bolt is not a proper tool for slaughter of equids they regain consciousness 30 seconds after being struck fully aware they are being vivisected." Dr Friedlander DVM & frmr Chief USDA Insp



  6. #6
    Join Date
    Dec. 13, 2010
    Location
    USA
    Posts
    15

    Default

    I've had excellent luck converting from pergolide to Evitex - a natural, herbal supplement in an apple cider vinegar base. Good luck!
    ~Patti Bartsch, Ph.D.~ Are you Naturally Unbridled? Find out at http://www.NaturallyUnbridled.com and get a free gift!



  7. #7
    Join Date
    Oct. 3, 2007
    Location
    PA
    Posts
    5,183

    Default

    I feel your pain. I am trying to dose a pony who can find the apple flavored powder in anything. Currently I am mixing it with applesauce and shooting it in his mourth - when I can catch him that is. My vet is going to get a non dosed gourmed for me to add to his little bit of grain to see if he will accept it. At this point he is very suspicious of anything I try to give him.



  8. #8
    Join Date
    Jan. 16, 2002
    Location
    West Coast of Michigan
    Posts
    36,321

    Default

    Time to desensitize her to getting liquid meds orally. You can buy oral dosing syringes for goats and calves at a farm supply, train the mare to tolerate it using something innocuous and non-medicated, and get her to the point where she will deal with it. It's like trailer loading, pulling manes or standing for the farrier: a matter of teaching and desensitization.
    Click here before you buy.



  9. #9
    Join Date
    Feb. 9, 2004
    Location
    Sunny CA
    Posts
    4,594

    Default

    Bodie would never eat a flavored powder. He gets 1.5 cc of liquid in his feed. I get it from Farmvet
    Steph

    http://community.webshots.com/user/stephanne014

    Rerider/Haydunker Clique

    RIP Barbaro, you were my hero!



  10. #10
    Join Date
    May. 21, 2008
    Location
    Sonoma County, California
    Posts
    2,608

    Default

    Quote Originally Posted by ptownevt View Post
    I found that the alfalfa flavored Gourmeds (from Wedgewood Pharmacy) along with a small scoop of alfalfa pellets added to his regular senior worked.
    Yes, this!

    You can also try dry powdered Jell-O mixed with the perg. powder and then over feed. Has worked for me as well. But that alfalfa flavor from wedgwood is amazing.



  11. #11
    Join Date
    Feb. 22, 2007
    Posts
    3,928

    Default

    I'm with deltawave, my guy was never good about deworming but he wouldn't eat his peroglide so we just worked on it. Eventually they get over it. I got really far by simply going up to him, sticking an empty syringe in his mouth, then give him a cookie. Rinse and repeat a million times (I'd go out about every hour at first). Now he's at the point where syringe=cookie, so he's pretty eager for it. I don't even have to halter him. I found spending some time training him to get over the syringe far easier than endlessly trying to devise ways to disguise the medication.



  12. #12
    Join Date
    Feb. 28, 2006
    Location
    The rocky part of KY
    Posts
    10,188

    Default

    We are good with the old guy eating Pergolide as a liquid top dressing mixed in flaxseed oil on top of sweet feed. Having been down the "mikey won't eat it" road for a few other things I think that our next step would be to train to the syringe if he should get tired of the current method. I did take a stab at desensitizing but just didn't stick with it long enough. He's better about the syringe now but no trooper, that's for sure.
    Courageous Weenie Eventer Wannabe
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  13. #13
    Join Date
    Jul. 23, 2001
    Location
    Maryland
    Posts
    1,963

    Default

    My girl just got started on pergolide in capsules. She doesn't mind it at all . . .



  14. #14
    Join Date
    Mar. 24, 2007
    Posts
    1,807

    Default

    You can also get pergolide in capsule form.......it is what I feed my boarders horse.....just dropped it into her beet pulp....never even noticed.

    Dalemma



  15. #15
    Join Date
    Sep. 25, 2005
    Location
    The Land of the Frozen
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    13,787

    Default

    The problem with pergolide is that a common side effect is going off feed and depression. My horse got pickier and pickier about eating, finally went off all feed and water completely, then laid down and just waited to die. I had to get her off the pergolide and she eventually came back around. Same thing happened the next time I tried to put her on it. Some horses never have this problem, some eventually develop it, some start showing it right away after being put on the drug. The Yahoo Cushings group has some info on this but beware - some of the people there are out to lunch radicals.



  16. #16
    Join Date
    Dec. 7, 2001
    Location
    Cullowhere?, NC
    Posts
    8,694

    Default

    When Monstr was on Pergolide liquid, it was a very small syringe. The dose was only 1 ml, which isn't much liquid. He was also fussy about worming, and, at 17.3, could easily have his way. But he got to where I could walk up to him in the paddock, stick the tiny syringe in the corner of his mouth, and squirt. He barely knew I'd put anything there. If it isn't a problem for you to give it daily, doing the liquid might be worth a try.
    "One person's cowboy is another person's blooming idiot" -- katarine

    Spay and neuter. Please.



  17. #17
    Join Date
    Aug. 25, 2005
    Location
    Northeast
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    12,235

    Default

    Over the years I have known numerous horses on pergolide. Usually the method of choice was a liquid, which amounted to a 1 ml of volume, the dosage being adjusted to that. This was a compounded medication, made up by a pharmacist by prescription.

    I never saw a horse reject it in grain, nor did I see any of the adverse effects cited by Adventura Two. I did see horses eventualy decline despite the patient efforts of everyone involved.
    Some riders change their horse, they change their saddle, they change their teacher; they never change themselves.



  18. #18
    Join Date
    May. 22, 2002
    Location
    somewhere between middleaged and dead
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    1,908

    Default

    Pergolide is a known appetite suppressant. As Adventura states. Documented, just google it. To the OP about changing over the horse's feed...change it back for the simplest solution although I can't believe they had the horse on a corn based feed for a Cushings horse. Or go thru the protocol of starting with very low dosages and slowly increasing the Pergolide. Again, the cushings yahoo group has some extremely good advice.



  19. #19
    Join Date
    Oct. 14, 2004
    Location
    Connecticut
    Posts
    9,067

    Default

    Could you start with a very small amount to the feed, let her get used to that and gradually increase over time until you reach the full dose?

    I tried garlic one summer for flies and my mare would not touch it, so I did as stated above and it worked.
    MnToBe Twinkle Star: "Twinkie"
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  20. #20
    Join Date
    Nov. 1, 2008
    Location
    NY
    Posts
    1,106

    Default

    Pergolide IS a known appetite suppressant. STEP 1: Take equine off pergolide and get him eating a low-starch feed that he likes
    STEP 2: Gradually reintroduce pergolide in small increments until you reach the desired dosage (we found that the Smartpak pergolide was very unpalatable-people here are correct that Wedgewood is the way to go; they will send you samples of the treats and also have capsules and a variety of flavored powders)
    JB-Infinity Farm
    www.infinitehorses.com



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