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  1. #1
    Join Date
    Feb. 6, 2003
    Posts
    1,377

    Default Quest vs Panacure Power Pac - why one, versus the other?

    I have used both, and am wondering why or why not use one over the other? Experts, please chime in!



  2. #2
    Join Date
    Dec. 13, 1999
    Location
    Greensboro, NC
    Posts
    35,538

    Default

    Moxidectin does not kill EL3.

    PP kills all stages.

    Moxidectin paralyzes the worms, which allows them to just slide out, no harm, no foul.

    PP kills the worms, and they decay more or less in place. This causes little ulcers, which then *can* (not will) mimic the colicky issues caused by their emergence alive. This typically occurs around Day 14 (Day 1 being the first day of the pp)

    *I* have not had a horse show any issues with this.

    If you have fenbendazole-resistant strongyles, chances are you're going to be less effective against the encysted strongyles as well.
    ______________________________
    The CoTH CYA - please consult w/your veterinarian under any and all circumstances. - ET



  3. #3
    Join Date
    Mar. 7, 2003
    Posts
    4,057

    Default

    excerpted from Strongyles: The Worst of the Worms, written by Karen Briggs for theHorse.com :

    It's only quite recently that we've been able to tackle the problem of encysted small strongyles, which are left completely unscathed by most deworming drugs, including ivermectin. Only two drugs are considered larvicidal against encysted small strongyles: Moxidectin (at 0.4 mg/kg) and fenbendazole (10 mg/kg daily for five consecutive days), which are both known to kill significant proportions of the encysted cyathostome larvae within the gut mucosa.

    Recent studies have found that moxidectin's larvicidal effect was evident within nine days after treatment, and that larvae died within the cysts without inciting any inflammatory reaction. Various researchers have noted improvements in the appearance of the equine gut after treatment with larvicidal dewormers.
    Moxidectin effectively kills encysted strongyles with a single dose. Moxidectin is also effective against bots and neck threadworms, while fenbendazole (PP) is not.

    On the downside, moxidectin has a lower margin of safety compared to other dewormers. Care must be taken to administer the appropriate dose by weight. My vet does not recommend it for severely debilitated animals.



  4. #4
    Join Date
    Dec. 13, 1999
    Location
    Greensboro, NC
    Posts
    35,538

    Default

    Yes, there is a lot more mox does that a Power Pack doesn't - my assumption was the question was just about the encysted strongyles, sorry

    Mox is labeled as something NOT to give, not just a vet recommendation, for debilitated animals. It is stored in fat and a "slow release" chemical, so horses who have too little body fat (which includes the contraindicated foals as well), and yes, even a very healthy but fit and low body fat horse, should never be given moxidectin.
    ______________________________
    The CoTH CYA - please consult w/your veterinarian under any and all circumstances. - ET



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