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  1. #1
    Join Date
    Dec. 9, 2002
    Location
    Hollis, NH USA
    Posts
    416

    Default Legend and Adequan regimen

    To those who use Legend and Adequan, what is your regimen? I think the Adequan is supposed to be given weekly for 8 weeks and then monthly after that and I'm wondering who does the Legend as well and when one would administer that.



  2. #2
    Join Date
    Feb. 9, 2005
    Location
    Upper Midwest
    Posts
    5,640

    Default

    Different Uses. Adequan heals cartilage and Legend deals with inflamation. Adequan is supposed to be long-lasting. Legend is like "legal" horse asprin. I believe Legend can also be injected right into a joint (someone help me there)?

    Adequan: http://www.ctrdvm.com/html/medicatio...dequan%20nchor
    Legend: http://www.ctrdvm.com/html/medications_legend.html

    Recommended dosing, etc. is in the article.
    Siouxland Sporthorses: http://slsfarm.blogspot.com/

    DIY Journey of Remodeling the Farmette: http://weownblackacre.blogspot.com/



  3. #3
    Join Date
    Nov. 13, 2007
    Location
    NW Louisiana
    Posts
    5,185

    Default

    SmartPak had an article on their website not too long ago about injectable HA (Legend) vs. Oral HA. The research done indicated that oral HA led to higher and more consistent levels of HA in the blood than the injectable. Blood HA levels are supposed to correlate to the amount of HA that is available to help with joint health.

    So you might consider an oral like GrandHA. It's cheaper than Legend, and it works really well for my 19-yo dressage mare.



  4. #4
    Join Date
    Sep. 13, 2002
    Location
    Azle, Teh-has
    Posts
    7,691

    Default

    Quote:
    Different Uses. Adequan heals cartilage and Legend deals with inflamation. Adequan is supposed to be long-lasting. Legend is like "legal" horse asprin. I believe Legend can also be injected right into a joint (someone help me there)?



    arg. negative.
    Nothing heals cartilage.
    Come-on guys. We have our own private Reed here on the boards. Pay attention to his posts. Luckily I've spent countless hours talking to him about this stuff.

    Also, we must rememeber that Adequan is tested according to the loading dose. Who knows if it is helpful monthly. My guess is not as it is the strongest on day...3? I believe.

    This is Reed's:

    To summarize these two types of drugs, sodium hyaluronate is primarily an anti-inflammatory that may help stabilize the environment in and around the synovium along with stabilizing the viscosity of the synovial fluid. Adequan protects the articular cartilage (chondroprotective) from the destructive enzymes released in joint inflammation. In both instances neither drug has been shown to reverse damage incurred by hyaline cartilage. That leads us to the next generation of drugs that, in conjunction with anti-inflammatory treatments has been shown to regrow the articular surface, reversing the effects of DJD.
    http://kaboomeventing.com/
    http://kaboomeventing.blogspot.com/
    Horses are amazing athletes and make no mistake -- they are the stars of the show!



  5. #5
    Join Date
    Feb. 9, 2005
    Location
    Upper Midwest
    Posts
    5,640

    Default

    OMG alert the media! I was sloppy in my answer. You are right. I was wrong.

    I'm sorry I bothered.


    Quote Originally Posted by purplnurpl View Post
    Quote:
    Different Uses. Adequan heals cartilage and Legend deals with inflamation. Adequan is supposed to be long-lasting. Legend is like "legal" horse asprin. I believe Legend can also be injected right into a joint (someone help me there)?



    arg. negative.
    Nothing heals cartilage.
    Come-on guys. We have our own private Reed here on the boards. Pay attention to his posts. Luckily I've spent countless hours talking to him about this stuff.

    Also, we must rememeber that Adequan is tested according to the loading dose. Who knows if it is helpful monthly. My guess is not as it is the strongest on day...3? I believe.

    This is Reed's:

    To summarize these two types of drugs, sodium hyaluronate is primarily an anti-inflammatory that may help stabilize the environment in and around the synovium along with stabilizing the viscosity of the synovial fluid. Adequan protects the articular cartilage (chondroprotective) from the destructive enzymes released in joint inflammation. In both instances neither drug has been shown to reverse damage incurred by hyaline cartilage. That leads us to the next generation of drugs that, in conjunction with anti-inflammatory treatments has been shown to regrow the articular surface, reversing the effects of DJD.
    Siouxland Sporthorses: http://slsfarm.blogspot.com/

    DIY Journey of Remodeling the Farmette: http://weownblackacre.blogspot.com/



  6. #6
    Join Date
    Jan. 16, 2002
    Location
    West Coast of Michigan
    Posts
    36,321

    Default

    SmartPak had an article on their website not too long ago about injectable HA (Legend) vs. Oral HA. The research done indicated that oral HA led to higher and more consistent levels of HA in the blood than the injectable.
    Remember that SmartPak is also in the business of selling oral supplements. I haven't seen the article referenced above, but would be curious to know if it was actually based on science or the research of others or if it's just one of their easy-reader blurbs that pop up on the website. Would love to see the actual citation if somebody has it.

    Any time you're using a drug "off label" (and it happens a lot) you're accepting the fact that you are not going to be able to be as sure of consistent results as if you were following the regimen(s) that have been studied. This doesn't mean it can't or shouldn't be used off-label, but the level of evidence that it works falls off sharply. And this goes 10x for oral joint supplements, which have virtually no evidence to BEGIN with.

    I will probably do a course of Adequan on Bonnie this spring (she just had her hocks done for the first time) per the vet's recommendation, using the standard 28-day regimen and taking it from there. Given the difficulty in gauging response to ANY therapy in a patient who can't speak, I like to do things in a very singular way. AFTER seeing how the hock injections go, and IF the proper Adequan trial works, THEN I may try monthly injections (off label, yup, I get it) AND observe closely. One intervention at a time, see what happens, go from there.
    Click here before you buy.



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