Anyone know why you do not feed BL with NSAIDS?

[vbunny]

Basically, the above question :). I read on the BL solution bottle that it is not to be used in conjunction with NSAIDS, and I am curious why. Does it bother their belly, get toxic or could they just have a broken leg and be running around sound with it due to the high dose of pain killers?

TIA

[atr]

Bothers their belly--Devil's Claw is not without side effects, stomach irritation being one of them.

[Equibrit]

Their advertising;

Vitamin B-12 Supplement for Horses The Horse Journal's Two-Time #1 ranked natural pain relief formula! The Horse Journal proved a serving of B-L Solution is equal to 1.5 - 2.0 grams of Phenylbutazone, with a cost-to-benefit ratio that is unbeatable. No side effects with B-L Solution. Feed 1 oz daily for 1100 lb horse. 1 oz measuring cap included. This is a B12 Supplement. Do not give to pregnant mares.


Advertised as a B-12 supplement but the leading active ingredient is devils claw.

"Because of its bitterness and associated gastric stimulatory effect it is wise to be cautious in the use of Devil’s Claw on individuals with known gastric ulceration."

[BumbleBee]

If it isn't a steroid, and it is an anti-inflamitory.... it is a Non Steroidal Anti Informatory. Just because it's a herb doesn't mean it isn't a drug.

My mare actually did fine on bute for years ... I switched her to BL and she had ulcers within days. We are talking colic inducing ulcers.

[Equibrit]

http://www.vetherb.com/library/DevilsClawindepth.html
"Devil's Claw and a number of other plant derived anti-inflammatories all work at a variety of levels in a similar way to NSAIDs but generally without the side effects. The full mode of action has yet to be established. However, harpagoside, the principal marker compound found in Devil’s Claw has been shown to interfere with the mechanisms that regulate calcium influx into cells. Calcium influx is required for activation of the enzyme (phospholipase A2) that triggers the cascade of reactions which produce inflammatory eicosanoids. This action is a common property of many anti-inflammatory and analgesic agents and partially explains Devil’s Claw’s anti-inflammatory effect.
The plant has been shown to inhibit the production of leukotrienes and tumour necrosis factor alpha (TNFα). This is significant because TNFα stimulates tissue degeneration and depresses the synthesis of protein. Unlike NSAIDs Devil’s Claw does not alter the activity of cyclooxygenase 1 - an enzyme involved in the production of prostaglandins. This also suggests that it will not have the same irritant effects on the stomach. Although because of its bitterness which stimulates acid production it may aggravate conditions of gastric ulceration."

[deltawave]

If it isn't a steroid, and it is an anti-inflammatory.... it is a Non Steroidal Anti Inflammatory. Just because it's a herb doesn't mean it isn't a drug.


Brilliant. :) (I fixed the spelling, though) :p

[BuddyRoo]

ditto others.

Just because something is "natural" does not mean that it's without side effects.

Devil's Claw is known to cause some issues similar to other NSAIDs and therefore, you don't give both at once in order to avoid complications. (similarly, you wouldn't give banamine and bute concurrently)