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Hillside H Ranch
Feb. 12, 2010, 09:14 AM
I received this press release yesterday. Thought some of you here may enjoy it; I always love hearing about the newest cutting edge repro technology!
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Minitube International Press Release

For Immediate Release: February 11, 2010

Breakthrough in equine reproduction: live foal born after embryo biopsy, vitrification and transfer

Minitube International has achieved a scientific breakthrough that will allow for genetic testing and preservation of equine embryos. The world’s first foal from a biopsied and vitrified embryo transferred into a surrogate mare was born on Wednesday January 27, 2010 at Minitube International Center for Biotechnology in Mount Horeb, WI. Both the mother “Lola” and foal are doing well. The birth of “Biopsita” marks a new era in horse breeding, providing horse breeders with an opportunity to directly test embryos for genetic traits including gender, coat color, geneti c diseases, etc., and select desirable genetics from stallion and mare combinations. The study will be presented at the 10th International Symposium on Equine Reproduction being held in Kentucky this July.



According to Mats Troedsson, DVM, PhD, Dipl. ACT the Director of the Gluck Equine Research Center at the University of Kentucky and Director of Equine Research for Minitube International, “Embryo transfer and cryopreservation have been steadily gaining traction in equine reproduction as the technology further develops and the equestrian community adjusts registry requirements. But the ability to genetically screen an equine embryo before transfer would change horse breeding as we know it today. The economics would just make sense.”



To make Preimplantation Genetic Diagnosis (PGD) or genetic screening of an equine embryo practical, the embryo needs to be biopsied, vitrified and later transferred into a recipient. Dr. John Dobrinsky, PhD, the Executive Director of the Minitube International Center for Biotechnology, credits his team and Minitube’s dedication as key to the success. “Our scientific team and research farm staff are second to none in bringing new biotechnologies to an applied veterinary and farm level,” Dr. Dobrinsky stated. “Seeing that foal walking around the stall is a strong reminder of the scientific advancements that can be made when you combine a stellar team with a stron g support environment like the one here at Minitube.” Dr. Dobrinsky utilized one of Minitube’s recently unveiled commercial products in the study: the EQUIPRO Vit-Kit™, a complete equine direct transfer vitrification kit commercially available for equine veterinarians.



Minitube, in collaboration with the Madison Equine Clinic and Hagyard Equine Medical Institute, currently offers equine vitrification and embryo transfer services throughout the United States and will be adding Preimplantation Genetic Diagnosis (PGD) to its available services. Madison Equine Clinic is a full-service equine veterinary clinic based in Wisconsin offering clients a complete range of advanced reproductive services for the stallion, mare and foal from its Mount Horeb location. Based in Lexington, KY, the Hagyard E quine Medical Institute has practiced veterinary medicine for more than 133 years and is currently composed of over 60 experienced veterinarians, with 13 board certifications in specialty areas of Medicine, Surgery, Critical Care, and Theriogenology.



Minitube International is a biotechnology company specializing in advanced reproduction technologies and cell biology. With partners and clients in the agricultural, veterinary, medical and research communities, Minitube is active in the fields of food animal production, companion and sport animal breeding, clinical research and cellular diagnostics.”

Contact Information: Mari Dean, Minitube, 608.845.1502

http://www.minitube.com/species_products.asp?Cat_ID=3&MI_ID=40

EquusMagnificus
Feb. 12, 2010, 09:30 AM
Interesting!

HSGF
Feb. 12, 2010, 10:52 AM
We are also currently working on vitrification of Equine embryos at the Ontario Veterinary College...I am very excited about it!

bloomingtonfarm
Feb. 12, 2010, 11:07 AM
Depressing... The day where the 'perfect' foal will be manufactured in the lab seems to get closer and closer. The clone thing was bad enough I thought.


Some day we won’t even have to own a mare. We will just have to sit down in front of our computer and order a foal with the color, the height and all the characteristics that we want and the lab will provide the foal for delivery in 11 months….

stoicfish
Feb. 12, 2010, 11:54 AM
That is interesting.
Not too worried about it having that much affect on breeding in my lifetime. Right now they can only test for the same things as they can in "on the ground horses", sex, color, and some genetic diseases. Until the entire horse genome is mapped and all the genes are understood as well as their interactions and regulation, we are a long ways off ordering what we want. Good news is if we are at that point with horses, humans will likely have fixed most diseases like cancer, diabetics, Alzheimer’s, heart disease, aging, etc etc.
Cheer up it isn't really that big of a change in knowledge just a different technique, IMO.

They tested for disease in Human uteral for a while, they could also check for eye color and sex at the same time.

ne1
Feb. 12, 2010, 12:15 PM
the angus cattle breed has been hit by a couple of genetic defects in the last 2-3 years. we have one female, a granddaughter of the breed leading matron ($8m+ generated from sales of direct offspring alone) who is positive (as a carrier) for one of the defects but who does not express the defect. we will be flushing her this year using fertility treatment in order to get multiple embryos per flush (a practice not yet perfected for horses) and then all embryos will be sex-tested and also tested for the defect. the nice thing is that she will then carry her own defect-free, female offspring to term.

cattle reproductive technology has always been ahead of horses. there have been millions more samples to test and work with, and lets face it.... people need to eat. they don't necessarily need to own a horse.

dressurpferd01
Feb. 12, 2010, 12:34 PM
Fascinating. Used to work up there with the Lippis they have.

WaningMoon
Feb. 12, 2010, 12:34 PM
That is interesting.
Not too worried about it having that much affect on breeding in my lifetime. Right now they can only test for the same things as they can in "on the ground horses", sex, color, and some genetic diesesase. Untill the entire horse genome is mapped and all the genes are understood as well as thier interactions and regulation, we are a long ways off ordering what we want. Good news is if we are at that point with horses, humans will likely have fixed most diseases like cancer, diabetics, Altimers, heart disease, aging, etc etc.
Cheer up it isn't really that big of a change in knowlege just a different technique, IMO.

They tested for diesease in Human uteral for a while, they could also check for eye color and sex at the same time.

Sorry, and truly not being a bitch, that one just gets to me too much, that's all. :) altimers = alzheimers

stoicfish
Feb. 12, 2010, 01:13 PM
Sorry, and truly not being a bitch, that one just gets to me too much, that's all. :) altimers = alzheimers
LOL that is bad. I spell check my posts, I must have not got the right version. There will be tons more spelling errors. I am so used to having "spell check" fix things for me. Thank you for pointing that out and no disrespect intended.

pintopiaffe
Feb. 12, 2010, 04:19 PM
Oh, MAN... that type of 'guarantee' would be SOOOO tempting for something like a broodie in her last few years of competency...

OTOH, it's a little scary, in that already I think that competition 'trends' get too much attention (flashy front end vs. correct... super-hot-fancy vs. all around correct etc.) and I could see how this would make it even moreso...

Very, very interesting. Will there be a future career for "Equine Ethicist" ? :lol:

J-Lu
Feb. 12, 2010, 10:12 PM
. Good news is if we are at that point with horses, humans will likely have fixed most diseases like cancer, diabetics, Alzheimer’s, heart disease, aging, etc etc.
Cheer up it isn't really that big of a change in knowledge just a different technique, IMO.


OK, my turn to poke in good fun. Diseases like.....(all that stuff) and aging? Aging - a disease? :winkgrin: We are nowhere near fixing any of those issues. Part of the problem is that people want to eat their cake (and lots of supermarket meat and not exercise) and be disease free, too.

I suspect that this technology will be cost-prohibitive for quite some time. And while we can screen for disease, we have no idea how to screen for "super athlete who will stay sound through the late teens and pass amazing characteristics onto offspring".

Cattle producers are ahead of the game in terms of genetics. But the end goal is more defined: produce muscle mass for marbled meat in a thrifty way in terms of metabolism so it is cost-effective to feed them. That's physiology. The end goal in horse breeding is much more elusive in terms of genetics. Loose movement with sit ability plus good mind and a "up" temperament, in addition to a specific sex, size and color.... yeeeaaaahhhhhhh.

stoicfish
Feb. 12, 2010, 11:43 PM
OK, my turn to poke in good fun. Diseases like.....(all that stuff) and aging? Aging - a disease? :winkgrin: We are nowhere near fixing any of those issues. Part of the problem is that people want to eat their cake (and lots of supermarket meat and not exercise) and be disease free, too.


Well actually that might be an interesting topic for another board, how we view diseases. Generally we think of aging as a natural, inevitable process and cancer a disease, or not a natural process. But their is evidence that aging is genetically linked and also has environmental factors, much like cancer.

They have cancer cells that are immortal - http://news.bbc.co.uk/2/hi/health/3670495.stm
More recent research that challenges the telomere theory.

http://longevity-science.org/Aging.html
http://www.senescence.info/telomeres.html
http://www.senescence.info/causes.html

J-Lu
Feb. 13, 2010, 12:26 AM
Stoicfish, I'm a professional scientist and sounds like you may be, too. Happy to take a conversation to PM.

dr j
Feb. 13, 2010, 01:10 AM
cattle reproductive technology has always been ahead of horses. there have been millions more samples to test and work with, and lets face it.... people need to eat. they don't necessarily need to own a horse.

Cattle RT even lead the way for human ART. The director of the first embryology lab (human) I worked with had a degree in dairy science and learned his "art" doing cattle embryo work! Moved to humans as ART become more and more desired.

crownridgefarms
Feb. 13, 2010, 07:50 AM
Dislike the idea.
Where is the anticipation and excitement of waiting 11 months to see what years of planning and researching result in? Matching this stallion with this mare in hopes of getting this foal. I am not a fan of trying to fix something that is not broken.

EquusMagnificus
Feb. 13, 2010, 10:44 AM
Depressing... The day where the 'perfect' foal will be manufactured in the lab seems to get closer and closer. The clone thing was bad enough I thought.


Some day we won’t even have to own a mare. We will just have to sit down in front of our computer and order a foal with the color, the height and all the characteristics that we want and the lab will provide the foal for delivery in 11 months….

Oh I agree with you Suzanne, I think it is interesting from a science point of view, but I am not sure I would do it.

I believe we are, with all our super technologies, allowing defects to be bred into horses, the species. Advancements are a double-edged sword...