EPM Marquis and DMSO

[Bellfleur]

Anyone heard of the study about adding 10cc DMSO to the daily dose of Marquis to seriously improve the transfer / effectiveness??????

Saw one study done and published December 3rd 2008

I have heard nothing since then and not many people/vets seem to have heard of the study.

Called Bayer and they said 'we cannot say since it is only labeled for use the way it is' No help there.


ABSTRACT

Triazine-based antiprotozoal agents are known for their lipophylic characteristics and may therefore be expected to be well absorbed following oral administration. However, although an increase in lipid solubility generally increases the absorption of chemicals, extremely lipid-soluble chemicals may dissolve poorly in gastrointestinal (GI) fluids, and their corresponding absorption and bioavailability would be low. Also, if the compound is administered in solid form and is relatively insoluble in GI fluids, it is likely to have limited contact with the GI mucosa, and therefore, its rate of absorption will be low. Based on the above considerations, we sought a solvent with low or no toxicity that would maintain triazine agents in solution. As the oral route is most preferred for daily drug therapy, such a solvent would allow an increased rate of absorption following oral administration. In present study, it was demonstrated that dimethylsulfoxide (DMSO) increased the oral bioavailability of toltrazuril sulfone (Ponazuril) threefold, relative to oral administrations of toltrazuril sulfone suspended in water. The cross-over study of toltrazuril sulfone formulated in DMSO indicated that the absolute oral bioavailability of toltrazuril sulfone in DMSO is 71%. The high bioavailability of the DMSO-preparation suggests that its daily oral administration will routinely yield effective plasma and cerebral spinal fluid (CSF) concentrations in all horses treated. Also, this improved formulation would allow clinicians to administer loading doses of toltrazuril sulfone in acute cases of Equine Protozoal Myeloencephalitis. Another option would involve administration of toltrazuril sulfone in DMSO mixed with feed (1.23 kg daily dose) meeting the US Food and Drug Administration (FDA) recommendations for the levels of DMSO permissible in pharmaceutical preparations.

[Yip]

Do you have a source for 100% pure medical grade DMSO?

If not, I wouldn't even consider it.

DMSO from a feed store can be used topically, but I would never use it internally since it isn't pure and labeled for internal use.

DMSO can be miraculous or deadly, depending on how and where it's used. Don't ask me how I know that.

If you want to try this, have your vet get the medical grade DMSO and give you instructions for administering it. I have heard that some vets are using DMSO IV with severe founders and it is nothing short of a miracle.

[Bellfleur]

I think the medical grade DMSO comes from Jeffers. I just mixed the DMSO and the Marquis in a small ramekin dish and then sucked it back into a syringe. Needs to be fed immediately then. Seemed to work well or at least as well as the Marquis alone worked as the horse completely recovered (so far anyhow)

[lindsay_aggie]

Common treatment for acute neurological problems includes DMSO added to fluids, so it makes sense. If I remember correctly you do have to be careful and do frequent bloodwork (hematocrit) to check for hemolysis. The DMSO causes red blood cells to burst if given to frequently and/or in too much quantity.

[eventrider]

I recently treated my horse for EPM. We did not use Marquis, because there have been studies to show that it is not totally effective over the 30 days of treatment. We used Baycox, made by Bayer. You stomach tube them with the Baycox 2 times, 3 days apart. We also jugged with DMSO at the same time as Baycox treatment. It is fairly common on the track and with vets that treat a lot of EPM cases. I cannot remember the amount of DMSO, but my vet was adamant that it had to be done with the treatment. Worked like a charm! The horse stunk for about 3 days!!!